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Oxidation and iodination Iodide trappedby follicular cells is carried across the apical mem-brane by another transporter termed ‘pendrin’ andoxidized by the membrane bound thyroidperoxidase enzyme to iodinium (I+) ions orhypoiodous acid (HOI) or enzyme-linked hypo-iodate (E-OI) with the help of H2O2.

The Action to ControlCardiovascular Risk in Diabetes (ACCORD) lipid trial evaluatedtreatment with fenofibrate compared with placebo amongpatients with type 2 diabetes treated with an open-label statinmedication.55 Among 5,518 patients randomized into the study,the addition of fenofibrate to statin therapy was not superiorto statin therapy alone. At this stage, the oocyte and thesurrounding follicle cells are closely apposed to one another.The oocyte in the follicle measures about 30